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Unethical practices - drug industry

Jason Kennerly jkenner at cello.gina.calstate.edu
Sat Jul 29 22:08:59 EST 1995

where do I mail the reply... maybe to spammer at sellout.eli.lilly.profit.com???

Fact is, Zoloft is *far more* selective than prozac... while prozac has 
been arguably demostrated marginally better at improving depression than 
Zoloft, and may be effective at lower doses for many forms of depression, 
this is because of the slight norepinephrine boost that Prozac provides 
and Zoloft does not!!! Zoloft is simply a drug that does its job too well.

What am I saying? that a patient who responds to Zoloft somewhat, but not 
entirely, but receives nothing from a dosage increase of zoloft alone may 
benefit ENOURMOUSLY from the addition of a small amount of Wellbutrin or 
one of the TCA antidepressants. Why? Because they target other systems - 
systems somewhat targeted by Prozac because Prozac is less selective.

My personal experience is totally different. I reacted to Imipramine 
(alone) with severe paradoxical depression and no improvement in any 
area. Prozac didn't do much for me either, but Zoloft curbs my 
aggression/violent desires very well. Prozac is too jittery for me - 
although with the way I take caffeine maybe its an interaction. Suffice 
to say I disliked it. It wasn't stimulanty, but JITTERY, like muscle 
tremors and stuff...

Anyways, enough spam... now for some biological stuff... a receptor 
binding list(!!!) backing up what I said..

From: lamontg at u.washington.edu (Lamont Granquist)
Subject: SSRI Neurochemistry
Date: 10 Sep 1994 23:13:54 GMT
Message-ID: <34teji$f6t at news.u.washington.edu>
As mentioned in the original article, these drugs typically have active
metabolites which may be significant.  Thus, actual in vivo activity may
be slightly different.
As mentioned in the original article, these drugs typically have active
metabolites which may be significant.  Thus, actual in vivo activity may
be slightly different.
                     Receptor Affinities for SSRI drugs
              (Values normalized to the IC50 for 5-HT reuptake)
     [Data Taken from: Internatn-Clin-Psychopharm, 9 suppl 1: 19-26 (1994)]
Clomiprimine  Fluoxetine   Sertraline    Paroxetine       Fluvoxamine
(Anafranil)   (Prozac)     (Zoloft)      (Paxil)          (Luvox)
SRI:      1   SRI:      1  SRI:       1  SRI:        1  SRI:      1
NARI:    14   NARI:    54  NARI:    840  NARI:     280  NARI:   160
DARI:  2900   DARI:   740  DARI:    250  DARI:   18000  DARI: 11000  
D1:     130   D1:    1500  D1:    33000  D1:     52000  D1:  >26000
D2:     290   D2:    4700  D2:   130000  D2:    180000  D2:   17000
H1:      36   H1:     470  H1:    53000  H1:    66,000  H1:    2900
ACh:     45   ACh:    445  ACh:    5800  ACh:      720  ACh:   8900
S1A:   1900   S1A:  12000  S1A: >530000  S1A:  >340000  S1A: >26000
S2A:     36   S2A:    100  S2A:   45000  S2A:    62000  S2A:   3200
S2C:    n/a   S2C:    235  S2C:     n/a  S2C:    69000  S2C:   1800
Alpha1:  40   Alpha1:2000  Alpha1:15000  Alpha1: 66000  Alpha1:1300
Alpha2:1200   Alpha2: 410  Alpha2: 9500  Alpha2:300000  Alpha2: 500
Beta: 15000   Beta:   264  Beta:  74000  Beta:  120000  Beta: 23000
Radioligands used in binding: 
D1:     SCH23390;    D2:     Spiperone;          5-HT1A: 5-OH-DPAT;  
5-HT2A: Ketanserin;  5-HT2C: Ly278584;           Alpha1: Prazosin; 
Alpha2: Idazoxan;    Beta:   Dihydroalprenolol;  H1:     Mepyramine; 
ACh:    QNB.

[speaking of metabolites, paxil has none that are active, zoloft's 
metabolite, while longer lasting is largely inactive, and Prozac's 
metabolite, extremely long lasting, is half as potent - making 
norfluoxetine the active drug!!!] 

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