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Stroke - help needed - easy question?

M anon1167 at nyx10.cs.du.edu
Tue Jun 6 12:06:54 EST 1995


David, a brief reply to you question:
Animal models have suggested that thrombolysis (dissolving the blood 
clot) can reduce stroke injury with a time frame of something like 1-2 
hours.  There is some concern that at longer post-ischemic intervals, 
thrombolysis may be associated with hemorrhage, but his is 
controversial.  Reperfusion of ischemic territory is obviously 
desirable,, but under some circumstantces, can lead to additional damage, 
noteably from whit blood cells.  There are experimental therapies to 
reduce this reperfusion injury, however.  Thrombolysis is being tried in 
human stroke patients and it appears promising; last winter a large 
European trial showed a significnat improvement.  A large US trial is in 
the analysis stage, I think.  

You should be able to find many references in medline or whatever you 
use.  





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