In AD, the symptoms are due to the disconnectin between
specific cortical areas. Therefore for fibroblast transplants
to be effective, they will have to form the
appropriate synaptic connections between these
cortical areas. They may have to produce ACh
but that may not be all.
More importantly, they will have to possess the potential to
respond to various neuronal signals in the visinity.
Devika CHin Grasby