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Ketanserin Metabolism in Brain

brian at pet.upmc.edu brian at pet.upmc.edu
Mon Dec 9 09:11:04 EST 1996

Does anyone out there know, either through personal experience or
knowledge of published literaturee, whether or not any of the following
are possibilities:

1) Oxidation of the reduced metabolite of ketanserin, ketanserin-ol, back
into the parent ketanserin in brain tissue.

2) hydroxylation of ketanserin in brain tissue to 6-OH-ketanserin

3) Blood-brain passage of 6-OH-ketanserin from periphery

Any help would be greatly appreciated...
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