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Goldman-Hodgkin equation : origin ??

Mathew V. Jones jonesmat at ohsu.edu
Mon Feb 12 12:57:10 EST 1996


In article <00003387+00000de6 at msn.com> Richard Norman, RNorman at msn.com
writes:
> They rise and fall together -- both indicate the state of openness of
channels.

I'm not sure this is true. The way I usually think about it is that
higher relative permeability means a better ability to compete with other
ions for occupancy of the pore. This can also be (but doesn't have to be)
thought of as a long dwell time in the pore relative to other ions. On
the other hand, ions that stay in the pore for a long time give rise to
smaller currents (number of ions passing through the pore per unit of
time). That means that ions with very high relative permeabilities may
have small conductances.  And in any case, neither of these things are
related to the "state of openness of channels" because conductance refers
only to the open channel, and relative permeability is measured by
comparing reversal potentials while holding gating properties constant. 

-Matt



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