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Death of cortical neurons

novotny Gerd.Novotny at uni-duesseldorf.de
Fri Feb 16 02:34:24 EST 1996


jan at neuroinformatik.ruhr-uni-bochum.de (Jan Vorbrueggen) wrote:
>
> In article
> <Pine.SUN.3.91.960214140041.29275E-100000 at great-gray.owlnet.rice.edu>
> smlamb at OWLNET.RICE.EDU (Sydney M Lamb) writes:
> 
>    I would like to get some estimate of the number of cortical neurons that
>    die per day in a normal person (no pathological condition present).  Better
>    yet, how about a normal adolescent, a normal young adult, and a normal
>    older person?
> 
> Somebody in Kiel, Germany, did a re-measurement of some classic experiments in
> this area about five years ago. It turns out that the old experiments had
> significant systematic errors - they didn't account for the fact that tissue
> from older persons contains less water and thus shrinks less when being
> fixed. This lowered the density of cells for older brains and by deduction the
> total number of cells, leading to an overestimate of the "natural" neuronal
> death rate by at least an order of magnitude. The rate seems to be pretty much
> independent of age; the total difference after 70 years of life is in the 3-5%
> range, IIRC.
> 
>    Also, what happens to the rate when alcohol is being consumed?
> 
> That probably depends non-linearly on the rate and duration of alcohol
> consumption. 
> 
> 	Jan
The name of the "somebody" in kiel is Haug, I think the papers were in
Am. J. Anat. or Anat. Rec.
Gerd Novotny



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