2 CFS Research Briefs - Organic Brain Dysfunction & Altered Gait

Jen guerra at webspan.net
Thu Jun 18 20:03:59 EST 1998

CFS (Chronic Fatigue Syndrome) Research Briefs

The following studies are all available on PubMed, a listing
of research journal articles
maintained by the U.S. National Institutes of Health. Authors,
titles, publication information and UI number are included at
the end of each summary. You can read the abstracts by going
to the PubMed website at http://www.ncbi.nlm.nih.gov/PubMed/
and inserting the UI number of the article into the search


     Researchers studied CFS patients and sedentary controls
with tests designed to
     measure instinctive and learned reaction to sensory
stimulation, using sound
     associated with a puff of air directed toward the eyeball
in order to cause the
     subject to blink.  They found that the CFS patients
reacted normally to both the
     sound and the airpuff, but "displayed impaired
acquisition of the eyeblink
     response using a delayed-type conditioning parameter."
In other words, the CFS
     patients reacted normally to the stimuli themselves, but
were abnormally slow to
     learn new reactions to stimuli.  What I think this means
is that the researchers made
     the sound and sent the puff of air toward the subject's
eye at the same time, and
     after this was done a few times, normally the subjects
should have instinctively
     learned to blink as soon as they heard the sound; but the
CFS patients were not
     able to do this as a normal person would. The researchers
say that this indicates
     an "associative deficit," and that CFS patients are
probably suffering from "organic
     brain dysfunction within a defined neural substrate."

UI number:  98263991

Authors:  Servatius RJ, Tapp WN, Bergen MC, Pollett CA,
Drastal SD,
Tiersky LA, Desai P, Natelson BH

Title:  "Impaired associative learning in chronic fatigue

Published:  Neuroreport 1998 Apr 20; 9(6):1153-1157


     Researchers studied the spatial (movement) and temporal
(speed) parameters of
     gait (walk) of 12 CFS patients.  They found significant
abnormalities in symmetry,
     which has to do with the movement of one side of the body
as compared to the
     other, as well as other abnormalities.  They also found
that these abnormalities
     did not change from the beginning to the end of the
exercise period, and so
     could not have been produced by fatigue.  The authors say
that this study
     strengthens the hypothesis that a dysfunction of the
central nervous system plays a
     part in the onset of CFS.

UI Number:  98202319

Authors:  Saggini R, Pizzigallo E, Vecchiet J, Macellari V,
Giacomozzi C.

Title:  "Alteration of spatial-temporal parameters of gait in
fatigue syndrome patients."

Publication:  J Neurol Sci 1998 Jan 21; 154(1):18-25.

Jen :)

Jen Munn's CFIDS Site

Jen's Walk on the Web

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