Course on Developmental Neurobiology
To be held 13th - 15th of August 1998
in the University of Kuopio, Finland
AIMS OF THE COURSE
This international course concentrates on the recent
development in the neuronal development.
Especially, the molecular aspects of developmental
processes will be emphasized. Speakers are
active researchers in their respective fields and
they will be asked to give an general introduction
into their topic and spend then the rest of their
talk illuminating the recent development and future
trends from the perspective of their own research.
One day will be spent in laboratory practices and
demonstrations on selected aspects of developmental neurobiology.
ORGANISING COMMITTEE
Dr. Eero Castrén, A.I. Virtanen Institute, University of Kuopio
Dr. Antero Salminen, Department of Neurobiology and Neuroscience,
University of Kuopio
TARGET GROUPS
The course is suitable for graduate students in the field
of neurobiology or developmental biology as
well as interested physicians in the fields of neurology,
psychiatry, pediatric neurology and child psychiatry.
APPLICATIONS
Students who want to participate in the laboratory demonstrations
and want to get the credits (1 point) of the course must pass
"a pre-exam". Otherwise the lectures are free to all. The exam is
based on the review papers published in Science
(Science 274:1109-1138, 1996):
Lumsden, A. and Krumlauf, R. Patterning the vertebrate neuraxis.
Science 274:1109-1115, 1996.
Tanabe, Y. and Jessell, T.M. Diversity and pattern in the
developing spinal cord. Science 274:1115-1123, 1996.
Tessier-Lavigne, M and Goodman, C.S. The molecular biology
of axon guidance. Science 274:1123-1133, 1996.
Katz, L.C. and Shatz, C.J. Synaptic activity and the construction
of cortical circuits. Science 274:1133-1138, 1996.
When you have read these articles, ask for exam questions from:
tapani.hyvonen at uku.fi and send
your answers (max. 1 page/question) to: eero.castren at uku.fi
PLACE
Laboratory demonstrations: Canthia building, KL3 and KL4
Lectures: A.I.Virtanen Institute, 3rd floor, Seminar room
FURTHER INFORMATION
Course HomePage: http://www.uku.fi/laitokset/aivi/devneuro.htm
Eero Castren, M.D.
A.I. Virtanen Institute
University of Kuopio
P.O.Box 1627
70211 Kuopio
Finland
Homepage: www.uku.fi/laitokset/aivi/eero.htm
e-mail: eero.castren at uku.fi
tel: +358-17-162 084
mobile: +358-50-520 7974
fax. +358-17-163 030
Tapani Hyvönen
A.I. Virtanen Institute
University of Kuopio
P.O.Box 1627
70211 Kuopio
Finland
e-mail: tapani.hyvonen at uku.fi
tel: +358-17-162 028
fax. +358-17-163 025
Program
Thursday, 13th of August
Laboratory demonstrations
LacZ-staining on developmentally expressed genes in transgenic mice
Neuronal stem cells: culture and differentiation
Friday, 14th of August
8.30 Dr. Eero Castrén: Opening of the course
Session 1. Molecular patterning of the CNS (Chairman: Eero Castrén)
8.45 Peter Gruss, MPI, Göttingen:
Homeobox genes and neuronal patterning
9.30 Urban Lendahl, Karolinska Institute:
Notch signaling
Coffee break
10.45 Seppo Vainio, University of Oulu:
Wnt signaling
11.30 Antero Salminen, University of Kuopio:
Basic helix-loop-helix proteins in neural and myogenic development
Lunch
Session 2. Neuronal differentiation and migration (Chairman: Antero Salminen)
14.00 Pertti Panula, Åbo Akademi:
Development of neurotransmitter systems
14.45 Maija Castrén, HYKS:
Neuronal migration and migration defects
15.30 Kai Kaila, University of Helsinki:
Molecular and biophysical bases of change from
GABA excitation to GABA inhibition in the neonate rat hippocampus
Saturday 15th of August
Session 3: Process outgrowth and axonal guidance (Chairman: Kai Kaila)
9.00 Jonas Frisén, Karolinska Institute:
EPH receptors and ligands in axon guidance
9.45 Heikki Rauvala, University of Helsinki:
Extracellular matrix and process outgrowth
Coffee break
Session 4: Refinement of neuronal networks (Chairman: Asla Pitkänen)
11.00 Mart Saarma, University of Helsinki:
Neuronal cell death
11.45 Eero Castrén, University of Kuopio:
Synaptic plasticity in cortical neurones
End of the course
