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re- low uric acid and MS

p.j.h kenneth.grant at worldnet.att.net
Fri Apr 2 02:02:13 EST 1999


what is oxidative stress?
Dr. Alan Wheatley <rawheatley at canadalane.demon.co.uk> wrote in message
news:rawheatley-3103992119120001 at canadalane.demon.co.uk...
> rcb5 at MSN.COM ("Ron Blue") wrote (7389, 29 Mar 1999)
>
> >[Uric acid as a scavenger in oxidative stress]
> >VERNACULAR TITLE:  A hugysav jelentp6ege az antioxidacios vedelemben.
> >AUTHORS:  Staub M
> >AUTHOR AFFILIATION:  Orvosi Vegytani, Molekularis Biologiai es
Patobiokemiai
> >Intezet, Semmelweis Orvostudomanyi Egyetem.
> >SOURCE:  Orv Hetil 1999 Feb 7;140(6):275-9
> >CITATION IDS:  PMID: 10071505 UI: 99170899
>
> flefever at ix.netcom.com(F. Frank LeFever) wrote (7396, 30 Mar 1999)
>
> >Hmmm...  I have a vague impression I may have challenged you to produce
> >such a reference, and here it is!  Provocative.  Hungarian, is it?
> >Will forward this to my work email as a reminder to look into it
> >further.
>
> Ron's point is supported by the following recent publication, which covers
> very similar ground to the ?Hungarian paper cited above:
>
>                    Uric Acid In EAE & Multiple Sclerosis
>      -------------------------------------------------------------------
> Hooper DC, Spitsin S, Kean RB, Champion JM, Dickson GM,Chaudhry I,
> Koprowski H, Proc Natl Acad Sci U S A 1998 Jan 20;95(2):675-680
> UI # 9435251
>        Thomas Jefferson University,
>        Center for Neurovirology,
>        Department of Microbiology and Immunology,
>        Philadelphia, PA 19107-6799
>        USA
>
> Abstract at:
> http://www.geocities.com/HotSprings/3468/uric_acid-peroxynitrite2-98.html
>
> What is intriguing me is why only uric acid? i.e., if the uric acid is
> being depleted by oxidative stress, why are not other anti-oxidants
> depleted also?
>
>                                                          Alan.
>
> Dr. Alan Wheatley at http://www.canadalane.demon.co.uk





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