an ALS Hypothesis

dag.stenberg at helsinki.nospam.fi dag.stenberg at helsinki.nospam.fi
Wed Feb 2 03:54:43 EST 2000

kenneth Collins <kpaulc at earthlink.net> wrote:
> of course, if, contrary to the hypothesis i've been discussing, the
> 'lesion' is, in fact, a genetic 'lesion' that's distributed theougout
> the supersystem, then it seems that the only way to possibly attack the
> 'lesion' would be through globally-distributed chemo approach, with
> respect to which, i'm out of my depth.

> it's just that it doesn't seem to be globally-distributed because
> sensory fx is unaffected. 

A genetic lesion can be in all cells and still be expressed only in a
subsystem (target tissue, cell type or whatever). There has to be some
coincidence (like something specific to motor neurons that makes the
global lesion activate in them only).

Dag Stenberg

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