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neurogenesis - NewSci Feb 12 2000

Ian McLeod ian_mcleod at primus.com.au
Sun Mar 5 04:13:08 EST 2000

So what is selective about Prozac in SSRI?

Have we found any evidence of neurogenesis in humans yet?  I mean definitive
evidence.  It appears that the smoking gun is there, but no firm suspects yet.

I myself am taking Prozac after reading the New Scientist article on Prozac.
It appears to be working, and apparently long term depression can leave
'scarring' (as my GP called it) on the brain.  I have been hoping that Prozac
would remedy this.

I can not detect any side effects.

I do not wish to use this discussion group for my own benefit.  I am interested
in the potential for neurogenesis for society as a whole.  It sounds too good
to be true.

But it appears that no firm evidence for neurogenesis in humans has been found
yet, apart from the smoking guns so to speak.

If anyone has anything to contribute, please write to me personally as well as
posting to this group.

Thank you.


"John H." wrote:

> Doesn't Prozac affect both serotonin and norepinephrine levels? I'm
> wondering if the elevation of the latter may provide a clue to the
> neurogenesis impulse.
> Or could it be a dampening of the cortisol elevation common in depression,
> particularly given the Nature article,
> Cortisol levels during human aging predict hippocampal atrophy and memory
> deficits.
> nature neuroscience . volume 1 no 1 . may 1998
> Now I have to go check up on CRH again ... .
> John H.
> Remove 4x
> <dag.stenberg at helsinki.nospam.fi> wrote in message
> news:898r9o$orr$1 at oravannahka.helsinki.fi...
> > >> Ian McLeod <ian_mcleod at primus.com.au> wrote:
> > >> > What about Prozac / flouxetine (?) - apparantly this has facilitated
> neuro$
> > >> > in the hippocampus in rats..
> > >>
> > >> I am presently confused - where did you find that data?
> > >> Dag Stenberg
> > Ian McLeod <ian_mcleod at primus.com.au> wrote:
> > > New Scientist.  I think it was the last quarter of last year although I
> can not recall
> > > the exact date.  Their web site is at www.newscientist.com
> >
> > Thank you for reminding me. This data was reported in the 1999 Society
> > for Neuroscience meeting (abstract 283.16) by Barry Jacobs and Casimir
> > Fornal, and NewScientist write about in in the issue of 6 November,
> > 1999. The study has not yet been published (according to a Medline
> > search today).
> >   Indeed, fluoxetine given to rats daily for a week increased
> > hippocampal neurogenesis, and Jacobs and Fornal build a theory of the
> > mechanism for antidepressive treatment on this finding. This finding was
> > discussed in this group some months ago, and I had again forgotten about
> > it.
> >
> > Dag Stenberg

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