sam-e causes brain damage?

larryhoover at my-deja.com larryhoover at my-deja.com
Mon Oct 9 09:05:16 EST 2000

In article <8rr6me$iuq$1 at bob.news.rcn.net>,
  "eric" <errock at rcn.com> wrote:
> ok, i stumbled accross the first one when reading a neurology
> group,
> I relize that the studies invovle SAM and not SAM-e, but again they
> linking the neural damage to elevated SAM and elevated methylation.
> Also, im fairly sure that ive heard of people reporting parkinsons
> from sam-e which im looking for evidence of on deja.

Eric, concerning this and subsequent postings, I would first be
concerned about the assumptions which underlie your conclusions. If
SAMe is used for antidepressant purposes, the  hypothesis is that it is
correcting an imbalance in biochemistry, i.e. the deficiency of SAMe
that is associated statistically with the symptoms of depression. The
studies you quote reflect purposeful imbalance in the opposite
direction. The fact that increasing SAMe levels from normal levels may
cause neurological damage does not in any way support the conclusion
that raising SAMe levels to normal levels from a deficient state must
also cause similar damage. The dose makes the posin, and the subject
pool differs as well.


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