Protein Structure.

dag.stenberg at nospam.helsinki.fi dag.stenberg at nospam.helsinki.fi
Sat Dec 29 13:29:32 EST 2001

Qinghong Zeng <beaglesci at yahoo.com> wrote:
> My major is Structural Biology, and our lab has good
> facilities to solve protein structures by X-ray. But
> now I am short of some proteins which are potentially
> important to study. If you are working at the study of
> some protein¡¯s functions and interested in its
> structure, please don¡¯t hesitate to contact with
> me.If the protein can be expressed in E.coli and is
> soluble,it will be good news to our collaboration.

I do not get the idea in this posting at all.
Do I understand that this guy wants to solve protein structures but has
no idea what to solve? And wants us, the world, to send him problems to
solve. He seems to imply that they can produce the protein under study
in E.coli to get enough to crystallize and then find the structure of.

I am very surprised because I happen to have contacts with a guy who has
been working on one multi-domain protein for a number of years, and is
not complaining about lack of ideas what to study, but about how the
structure still partially eludes them. He does not lack a problem, he
lacks the final solution.

So, beaglesci, what do you really want to do? If somebody has a problem,
would you do it (any problem) for them even if it takes 2-3 years? And why?

Dag Stenberg

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