The Blood Group problem!!!!

Richard L. Hall rhall at webmail.uvi.edu
Mon Jan 15 09:11:37 EST 2001

Good Morning,

Wrong!   Everybody has the "O-gene."

Genes are expressed as polypeptides or proteins.  The A and B 
antigens are NOT proteins but rather glycolipids found on the 
membranes of most human cells.  The proteins produced by  "A and B 
genes" are enzymes that catalyze the addition of specific sugars 
(either N-acetylgalactosamine or D-galactose) to a glycolipid 
consisting of L-fucose: D-galactose: N-acetylglucosamine: 
D-galactose: N-acetylgalactosamine:lipid. The five sugar glycolipid 
is sometimes called the 'H-antigen" although it is actually 
non-antigenic.  The A or B antigens are formed by the addition of 
either N-acetylgalactosamine or D-galactose to the H-antigen.

The so called "O gene" produces the glycosylating enzyme (or enzymes) 
producing the  "H-antigen."  There are "A-genes, B-genes, and "O 
genes" as well as an A-antigen, a B-antigen, and a "H-antigen" and 
they are apparently inherited in a Mendelian fashion.


>In human blood groups the AB blood type has a gene for type A blood inherited
>from one parent and a gene B inherited by the other parent, so you see there
>are no O genes in blood group AB therefore a baby with blood type O can not

Richard L. Hall, Ph.D.
Comparative Animal Physiologist

University of the Virgin Islands
2 John Brewers Bay
St. Thomas, U.S.V.I. 00802

340-693-1385 FAX

rhall at uvi.edu

"Live life on the edge...the view is always better"  rlh
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