Journal of Neuroscience, 2001 Sep 1;21(17):6475-9.
"...Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the
main active compound in marijuana, reduces neuronal
injury in neonatal rats ... These results provide
evidence that the cannabinoid system can serve to
protect the brain against neurodegeneration."
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11517236&dopt=Abstract
*******************************************************
Brain Research, 2000 Feb 28;857(1-2):183-7.
"The high dose THC-treated group showed significantly
less neocortical injury, compared to either the control
or low-dose THC groups (p<0.05). The striatum was markedly
protected by both low and high dose THC (p<0.001)."
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10700566&dopt=Abstract
************************************************************
Annals of the New York Acadamy of Sciences, 2000;899:274-82.
Neuroprotective antioxidants from marijuana.
"...cannabinoids can act as an antioxidants in neuronal
cultures ... In a head to head trial of the abilities
of various antioxidants to prevent glutamate toxicity,
cannabidiol was superior to both alpha-tocopherol
[vitamin E] and ascorbate [vita C] in protective capacity."
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10863546&dopt=Abstract
***********************************************************
Neuroscience Letters, 2001 Aug 31;309(3):197-201.
"Addition of Delta(9)-tetrahydrocannabinol [THC] to the culture
medium attenuated the toxicity produced by kainate. ... The
neuroprotective effect was blocked with the CB(1) receptor
antagonist, SR141716A, indicating a receptor-mediated effect."
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11514075&dopt=Abstract
*************************************************************
Proc Natl Acad Sci U S A, 1998 Jul 7;95(14):8268-73.
Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective
antioxidants.
"Cannabidiol and THC also were shown to prevent hydroperoxide-
induced oxidative damage as well as or better than other
antioxidants in a chemical (Fenton reaction) system and
neuronal cultures. Cannabidiol was more protective against
glutamate neurotoxicity than either ascorbate or alpha-
tocopherol, indicating it to be a potent antioxidant."
Full Study: http://www.pnas.org/cgi/content/full/95/14/8268http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9653176&dopt=Abstract
************************************************************
J Pharmacol Exp Ther, 2000 Jun;293(3):807-12.
Cannabinoids protect cells from oxidative cell death:
a receptor-independent mechanism.
"...submicromolar concentrations of Delta(9)-tetrahydrocannabinol
(THC), Delta(8)-THC, cannabinol, or cannabidiol ... prevented
serum-deprived cell death. ... The antioxidative property of
cannabinoids was confirmed by their ability to antagonize
oxidative stress and consequent cell death induced by the
retinoid anhydroretinol. Therefore, cannabinoids act as
antioxidants to modulate cell survival and growth of
B lymphocytes and fibroblasts."
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10869379&dopt=Abstract
************************************************************
NOTE: There are numerous studies that show THC IMPAIRS MEMORY.
However, while unacceptable to myself, such impairment resolves
within 24 hours of acute use and a couple weeks after chronic use.
Such impairment appears to be caused by reduction of acetylcholine.
http://IanGoddard.net
"To lengthen thy life, lessen thy meals." Benjamin Franklin
