THC is Neuro-Protective

Ian Goddard igoddard at erols.mom
Thu Jan 10 12:21:27 EST 2002

Journal of Neuroscience, 2001 Sep 1;21(17):6475-9.

"...Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the 
main active compound in marijuana, reduces neuronal 
injury in neonatal rats ...  These results provide 
evidence that the cannabinoid system can serve to 
protect the brain against neurodegeneration."



Brain Research, 2000 Feb 28;857(1-2):183-7.

"The high dose THC-treated group showed significantly 
less neocortical injury, compared to either the control 
or low-dose THC groups (p<0.05). The striatum was markedly 
protected by both low and high dose THC (p<0.001)."



Annals of the New York Acadamy of Sciences, 2000;899:274-82.

Neuroprotective antioxidants from marijuana.

"...cannabinoids can act as an antioxidants in neuronal 
cultures ... In a head to head trial of the abilities 
of various antioxidants to prevent glutamate toxicity, 
cannabidiol was superior to both alpha-tocopherol 
[vitamin E] and ascorbate [vita C] in protective capacity."



Neuroscience Letters, 2001 Aug 31;309(3):197-201.

"Addition of Delta(9)-tetrahydrocannabinol [THC] to the culture 
medium attenuated the toxicity produced by kainate. ... The
neuroprotective effect was blocked with the CB(1) receptor 
antagonist, SR141716A, indicating a receptor-mediated effect."



Proc Natl Acad Sci U S A, 1998 Jul 7;95(14):8268-73.

Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective

"Cannabidiol and THC also were shown to prevent hydroperoxide-
induced oxidative damage as well as or better than other 
antioxidants in a chemical (Fenton reaction) system and 
neuronal cultures. Cannabidiol was more protective against 
glutamate neurotoxicity than either ascorbate or alpha-
tocopherol, indicating it to be a potent antioxidant."

Full Study: http://www.pnas.org/cgi/content/full/95/14/8268


J Pharmacol Exp Ther, 2000 Jun;293(3):807-12.

Cannabinoids protect cells from oxidative cell death: 
a receptor-independent mechanism.

"...submicromolar concentrations of Delta(9)-tetrahydrocannabinol
(THC), Delta(8)-THC, cannabinol, or cannabidiol ... prevented
serum-deprived cell death. ... The antioxidative property of
cannabinoids was confirmed by their ability to antagonize 
oxidative stress and consequent cell death induced by the 
retinoid anhydroretinol. Therefore, cannabinoids act as 
antioxidants to modulate cell survival and growth of 
B lymphocytes and fibroblasts."



NOTE: There are numerous studies that show THC IMPAIRS MEMORY.
However, while unacceptable to myself, such impairment resolves
within 24 hours of acute use and a couple weeks after chronic use.
Such impairment appears to be caused by reduction of acetylcholine.

 "To lengthen thy life, lessen thy meals." Benjamin Franklin


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