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THC is Neuro-Protective

howard.olson at juno.com howard.olson at juno.com
Thu Jan 10 19:43:43 EST 2002


In article <3c3dc869.138850691 at news.erols.com>, Ian Goddard says...
>
> 
>Journal of Neuroscience, 2001 Sep 1;21(17):6475-9.
>
>"...Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the 
>main active compound in marijuana, reduces neuronal 
>injury in neonatal rats ...  These results provide 
>evidence that the cannabinoid system can serve to 
>protect the brain against neurodegeneration."
>
>http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11517236&dopt=Abstract
>
>*******************************************************
>
>Brain Research, 2000 Feb 28;857(1-2):183-7.
>
>"The high dose THC-treated group showed significantly 
>less neocortical injury, compared to either the control 
>or low-dose THC groups (p<0.05). The striatum was markedly 
>protected by both low and high dose THC (p<0.001)."
>
>http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10700566&dopt=Abstract
>
>************************************************************
>
>Annals of the New York Acadamy of Sciences, 2000;899:274-82.
>
>Neuroprotective antioxidants from marijuana.
>
>"...cannabinoids can act as an antioxidants in neuronal 
>cultures ... In a head to head trial of the abilities 
>of various antioxidants to prevent glutamate toxicity, 
>cannabidiol was superior to both alpha-tocopherol 
>[vitamin E] and ascorbate [vita C] in protective capacity."
>
>http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10863546&dopt=Abstract
>
>***********************************************************
>
>Neuroscience Letters, 2001 Aug 31;309(3):197-201.
>
>"Addition of Delta(9)-tetrahydrocannabinol [THC] to the culture 
>medium attenuated the toxicity produced by kainate. ... The
>neuroprotective effect was blocked with the CB(1) receptor 
>antagonist, SR141716A, indicating a receptor-mediated effect."
>
>http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11514075&dopt=Abstract
>
>*************************************************************
>
>Proc Natl Acad Sci U S A, 1998 Jul 7;95(14):8268-73.
>
>Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective
>antioxidants.
>
>"Cannabidiol and THC also were shown to prevent hydroperoxide-
>induced oxidative damage as well as or better than other 
>antioxidants in a chemical (Fenton reaction) system and 
>neuronal cultures. Cannabidiol was more protective against 
>glutamate neurotoxicity than either ascorbate or alpha-
>tocopherol, indicating it to be a potent antioxidant."
>
>Full Study: http://www.pnas.org/cgi/content/full/95/14/8268
>http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9653176&dopt=Abstract
>
>************************************************************
>
>J Pharmacol Exp Ther, 2000 Jun;293(3):807-12.
>
>Cannabinoids protect cells from oxidative cell death: 
>a receptor-independent mechanism.
>
>"...submicromolar concentrations of Delta(9)-tetrahydrocannabinol
>(THC), Delta(8)-THC, cannabinol, or cannabidiol ... prevented
>serum-deprived cell death. ... The antioxidative property of
>cannabinoids was confirmed by their ability to antagonize 
>oxidative stress and consequent cell death induced by the 
>retinoid anhydroretinol. Therefore, cannabinoids act as 
>antioxidants to modulate cell survival and growth of 
>B lymphocytes and fibroblasts."
>
>http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10869379&dopt=Abstract
>
>************************************************************
>
>NOTE: There are numerous studies that show THC IMPAIRS MEMORY.
>However, while unacceptable to myself, such impairment resolves
>within 24 hours of acute use and a couple weeks after chronic use.
>Such impairment appears to be caused by reduction of acetylcholine.
>
>
> http://IanGoddard.net
> 
> "To lengthen thy life, lessen thy meals." Benjamin Franklin


Thanks for the info Ian. Yet another nail in the coffin of the pseudo-scientific
"War On Drugs"!

Howard

>
>
>  

H R Olson,MA PhD
Medical Dept. 
Silicon Valley College
http://www.SiliconValley.edu




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