In article <3c3dc869.138850691 at news.erols.com>, Ian Goddard says...
>>>Journal of Neuroscience, 2001 Sep 1;21(17):6475-9.
>>"...Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the
>main active compound in marijuana, reduces neuronal
>injury in neonatal rats ... These results provide
>evidence that the cannabinoid system can serve to
>protect the brain against neurodegeneration."
>>http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11517236&dopt=Abstract>>*******************************************************
>>Brain Research, 2000 Feb 28;857(1-2):183-7.
>>"The high dose THC-treated group showed significantly
>less neocortical injury, compared to either the control
>or low-dose THC groups (p<0.05). The striatum was markedly
>protected by both low and high dose THC (p<0.001)."
>>http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10700566&dopt=Abstract>>************************************************************
>>Annals of the New York Acadamy of Sciences, 2000;899:274-82.
>>Neuroprotective antioxidants from marijuana.
>>"...cannabinoids can act as an antioxidants in neuronal
>cultures ... In a head to head trial of the abilities
>of various antioxidants to prevent glutamate toxicity,
>cannabidiol was superior to both alpha-tocopherol
>[vitamin E] and ascorbate [vita C] in protective capacity."
>>http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10863546&dopt=Abstract>>***********************************************************
>>Neuroscience Letters, 2001 Aug 31;309(3):197-201.
>>"Addition of Delta(9)-tetrahydrocannabinol [THC] to the culture
>medium attenuated the toxicity produced by kainate. ... The
>neuroprotective effect was blocked with the CB(1) receptor
>antagonist, SR141716A, indicating a receptor-mediated effect."
>>http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11514075&dopt=Abstract>>*************************************************************
>>Proc Natl Acad Sci U S A, 1998 Jul 7;95(14):8268-73.
>>Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective
>antioxidants.
>>"Cannabidiol and THC also were shown to prevent hydroperoxide-
>induced oxidative damage as well as or better than other
>antioxidants in a chemical (Fenton reaction) system and
>neuronal cultures. Cannabidiol was more protective against
>glutamate neurotoxicity than either ascorbate or alpha-
>tocopherol, indicating it to be a potent antioxidant."
>>Full Study: http://www.pnas.org/cgi/content/full/95/14/8268>http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9653176&dopt=Abstract>>************************************************************
>>J Pharmacol Exp Ther, 2000 Jun;293(3):807-12.
>>Cannabinoids protect cells from oxidative cell death:
>a receptor-independent mechanism.
>>"...submicromolar concentrations of Delta(9)-tetrahydrocannabinol
>(THC), Delta(8)-THC, cannabinol, or cannabidiol ... prevented
>serum-deprived cell death. ... The antioxidative property of
>cannabinoids was confirmed by their ability to antagonize
>oxidative stress and consequent cell death induced by the
>retinoid anhydroretinol. Therefore, cannabinoids act as
>antioxidants to modulate cell survival and growth of
>B lymphocytes and fibroblasts."
>>http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10869379&dopt=Abstract>>************************************************************
>>NOTE: There are numerous studies that show THC IMPAIRS MEMORY.
>However, while unacceptable to myself, such impairment resolves
>within 24 hours of acute use and a couple weeks after chronic use.
>Such impairment appears to be caused by reduction of acetylcholine.
>>>http://IanGoddard.net>> "To lengthen thy life, lessen thy meals." Benjamin Franklin
Thanks for the info Ian. Yet another nail in the coffin of the pseudo-scientific
"War On Drugs"!
Howard
>>>
H R Olson,MA PhD
Medical Dept.
Silicon Valley College
http://www.SiliconValley.edu
