IUBio

THC is Neuro-Protective

michael price nini_pad at yahoo.com
Sat Jan 12 07:23:47 EST 2002


howard.olson at juno.com wrote in message news:<3zq%7.12463$cD4.27213 at www.newsranger.com>...
> In article <3c3dc869.138850691 at news.erols.com>, Ian Goddard says...
> >
> > 
> >Journal of Neuroscience, 2001 Sep 1;21(17):6475-9.
> >
> >"...Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the 
> >main active compound in marijuana, reduces neuronal 
> >injury in neonatal rats ...  These results provide 
> >evidence that the cannabinoid system can serve to 
> >protect the brain against neurodegeneration."
> >
  Yeah but after that they no longer go through the maze for cheese.  The 
scientists had to switch to Tim-Tams or Oreos. : } 
> >http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11517236&dopt=Abstract
> >
> >*******************************************************
> >
> >Brain Research, 2000 Feb 28;857(1-2):183-7.
> >
> >"The high dose THC-treated group showed significantly 
> >less neocortical injury, compared to either the control 
> >or low-dose THC groups (p<0.05). The striatum was markedly 
> >protected by both low and high dose THC (p<0.001)."
> >
> >http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10700566&dopt=Abstract
> >
> >************************************************************
> >
> >Annals of the New York Acadamy of Sciences, 2000;899:274-82.
> >
> >Neuroprotective antioxidants from marijuana.
> >
> >"...cannabinoids can act as an antioxidants in neuronal 
> >cultures ... In a head to head trial of the abilities 
> >of various antioxidants to prevent glutamate toxicity, 
> >cannabidiol was superior to both alpha-tocopherol 
> >[vitamin E] and ascorbate [vita C] in protective capacity."
> >
> >http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10863546&dopt=Abstract
> >
> >***********************************************************
> >
> >Neuroscience Letters, 2001 Aug 31;309(3):197-201.
> >
> >"Addition of Delta(9)-tetrahydrocannabinol [THC] to the culture 
> >medium attenuated the toxicity produced by kainate. ... The
> >neuroprotective effect was blocked with the CB(1) receptor 
> >antagonist, SR141716A, indicating a receptor-mediated effect."
> >
> >http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11514075&dopt=Abstract
> >
> >*************************************************************
> >
> >Proc Natl Acad Sci U S A, 1998 Jul 7;95(14):8268-73.
> >
> >Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective
> >antioxidants.
> >
> >"Cannabidiol and THC also were shown to prevent hydroperoxide-
> >induced oxidative damage as well as or better than other 
> >antioxidants in a chemical (Fenton reaction) system and 
> >neuronal cultures. Cannabidiol was more protective against 
> >glutamate neurotoxicity than either ascorbate or alpha-
> >tocopherol, indicating it to be a potent antioxidant."
> >
> >Full Study: http://www.pnas.org/cgi/content/full/95/14/8268
> >http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9653176&dopt=Abstract
> >
> >************************************************************
> >
> >J Pharmacol Exp Ther, 2000 Jun;293(3):807-12.
> >
> >Cannabinoids protect cells from oxidative cell death: 
> >a receptor-independent mechanism.
> >
> >"...submicromolar concentrations of Delta(9)-tetrahydrocannabinol
> >(THC), Delta(8)-THC, cannabinol, or cannabidiol ... prevented
> >serum-deprived cell death. ... The antioxidative property of
> >cannabinoids was confirmed by their ability to antagonize 
> >oxidative stress and consequent cell death induced by the 
> >retinoid anhydroretinol. Therefore, cannabinoids act as 
> >antioxidants to modulate cell survival and growth of 
> >B lymphocytes and fibroblasts."
> >
> >http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10869379&dopt=Abstract
> >
> >************************************************************
> >
> >NOTE: There are numerous studies that show THC IMPAIRS MEMORY.
> >However, while unacceptable to myself, such impairment resolves
> >within 24 hours of acute use and a couple weeks after chronic use.
> >Such impairment appears to be caused by reduction of acetylcholine.
> >
> >
> > http://IanGoddard.net
> > 
> > "To lengthen thy life, lessen thy meals." Benjamin Franklin
> 
> 
> Thanks for the info Ian. Yet another nail in the coffin of the pseudo-scientific
> "War On Drugs"!
> 
> Howard
> 
> >
> >
> >  
> 
> H R Olson,MA PhD
> Medical Dept. 
> Silicon Valley College
> http://www.SiliconValley.edu




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