igoddard at erols.mom (Ian Goddard) wrote in message news:<3c3dc869.138850691 at news.erols.com>...
> Journal of Neuroscience, 2001 Sep 1;21(17):6475-9.
>> "...Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the
> main active compound in marijuana, reduces neuronal
> injury in neonatal rats ... These results provide
> evidence that the cannabinoid system can serve to
> protect the brain against neurodegeneration."
>>http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11517236&dopt=Abstract>> *******************************************************
>> Brain Research, 2000 Feb 28;857(1-2):183-7.
>> "The high dose THC-treated group showed significantly
> less neocortical injury, compared to either the control
> or low-dose THC groups (p<0.05). The striatum was markedly
> protected by both low and high dose THC (p<0.001)."
>>http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10700566&dopt=Abstract>> ************************************************************
>> Annals of the New York Acadamy of Sciences, 2000;899:274-82.
>> Neuroprotective antioxidants from marijuana.
>> "...cannabinoids can act as an antioxidants in neuronal
> cultures ... In a head to head trial of the abilities
> of various antioxidants to prevent glutamate toxicity,
> cannabidiol was superior to both alpha-tocopherol
> [vitamin E] and ascorbate [vita C] in protective capacity."
>>http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10863546&dopt=Abstract>> ***********************************************************
>> Neuroscience Letters, 2001 Aug 31;309(3):197-201.
>> "Addition of Delta(9)-tetrahydrocannabinol [THC] to the culture
> medium attenuated the toxicity produced by kainate. ... The
> neuroprotective effect was blocked with the CB(1) receptor
> antagonist, SR141716A, indicating a receptor-mediated effect."
>>http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11514075&dopt=Abstract>> *************************************************************
>> Proc Natl Acad Sci U S A, 1998 Jul 7;95(14):8268-73.
>> Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective
> antioxidants.
>> "Cannabidiol and THC also were shown to prevent hydroperoxide-
> induced oxidative damage as well as or better than other
> antioxidants in a chemical (Fenton reaction) system and
> neuronal cultures. Cannabidiol was more protective against
> glutamate neurotoxicity than either ascorbate or alpha-
> tocopherol, indicating it to be a potent antioxidant."
>> Full Study: http://www.pnas.org/cgi/content/full/95/14/8268>http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9653176&dopt=Abstract>> ************************************************************
>> J Pharmacol Exp Ther, 2000 Jun;293(3):807-12.
>> Cannabinoids protect cells from oxidative cell death:
> a receptor-independent mechanism.
>> "...submicromolar concentrations of Delta(9)-tetrahydrocannabinol
> (THC), Delta(8)-THC, cannabinol, or cannabidiol ... prevented
> serum-deprived cell death. ... The antioxidative property of
> cannabinoids was confirmed by their ability to antagonize
> oxidative stress and consequent cell death induced by the
> retinoid anhydroretinol. Therefore, cannabinoids act as
> antioxidants to modulate cell survival and growth of
> B lymphocytes and fibroblasts."
>>http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10869379&dopt=Abstract>> ************************************************************
>> NOTE: There are numerous studies that show THC IMPAIRS MEMORY.
> However, while unacceptable to myself, such impairment resolves
> within 24 hours of acute use and a couple weeks after chronic use.
> Such impairment appears to be caused by reduction of acetylcholine.
How about vasopressin?
