Testosterone is Neuroprotective

Ian Goddard igoddard at erols.mom
Tue Jan 22 10:11:05 EST 2002

 The New Scientist reports:

 Testosterone blocks Alzheimer's brain abnormality 
 Doses of testosterone might prevent a key brain 
 abnormality associated with Alzheimer's disease, 
 say US researchers. Their work in rats suggests 
 that older women as well as men should be given 
 testosterone to help prevent or treat the disease, 
 they say. ...

See Full Report: 

The study cited in that report was published in 
the Proceedings of the National Academy of Sciences.

I found the following supporting evidence via PubMed:


Brain Research, 2001 Nov 16;919(1):160-5.

Testosterone attenuates beta-amyloid toxicity in cultured 
hippocampal neurons.

Pike CJ.

Andrus Gerontology Center, University of Southern California, 3715 
McClintock Avenue, Los Angeles, CA 90089-0191, USA. cjpike at usc.edu

Accumulating evidence suggests that testosterone has neurotrophic
and perhaps neuroprotective actions. Thus, age-related depletion 
of testosterone may increase the brain's vulnerability to 
Alzheimer's disease and related disorders. To begin investigating
this issue, cultured neurons were exposed to the Alzheimer-related 
insult beta-amyloid in the presence of testosterone. beta-Amyloid
neurotoxicity was significantly reduced by testosterone via a 
rapid, estrogen-independent mechanism. These data may provide 
additional insight into the treatment of age-related 
neurodegenerative disorders.



Neuroendocrinol Lett, 2001 Jun;22(3):163-8.

Serum total testosterone is lower in men with Alzheimer's disease.

"MAIN FINDINGS: Our results suggested that low TT [total 
testosterone] may be a co-morbid feature of DAT [Dementia 
of the Alzheimer's Type] in men. However, low TT levels 
could also exacerbate the disease. ..."



J Neurochem, 2001 Jun;77(5):1319-26.

Testosterone-mediated neuroprotection through the androgen 
receptor in human primary neurons.

"These results indicate that androgens induce neuroprotection 
directly through the androgen receptor. These data suggest 
that androgens may also be of therapeutic value against 
Alzheimer's disease in aging males."




 "To lengthen thy life, lessen thy meals." Benjamin Franklin


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