IUBio Biosequences .. Software .. Molbio soft .. Network News .. FTP

Cannabinoids are potent neuroprotective agents

BilZ0r BilZ0r at TAKETHISOUThotmail.com
Fri Aug 15 18:04:45 EST 2003

>> Don't get me wrong, the the in vitro studies arn't directly
>> comparable to recreational/clinical usages of cannabinoids, but they
>> do point out a need for caution. Also, you say that no neurtoxicity
>> has been shown in vivo with sensible doses. It depends on how you
>> define sesnible doses, if we account for the usual interspecies
>> dosing changes, the doses given to mice to produce "neurotoxicity"
>> are not that outlandish. 
> The preponderance of evidence clearly points to strong neuroprotective
> effects in vitro.

Well that depends. Put the system under stress from excitotoxicity, 
cannabinoids (especailly exogenous) and you'll protect.

There are about 4 different research groups, and about 6 differen't 
articles that all show that t anandamide is neurotoxic.
Whether its CB1, VR1 or lipid raft mediated is the question.

That also brings me to the point: I wish people would start using and 
opiate/opiod style diferentiation for cannabinoids. I.e. Cannabinoids are 
any chemicals which bind to CB receptors, while cannabinates are anything 
which comes from cannabis.. or something like that anyways.

More information about the Neur-sci mailing list

Send comments to us at biosci-help [At] net.bio.net