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Rapid brain shrinkage an early sign of schizophrenia?

James Michael Howard jmhoward at arkansas.net
Mon Aug 18 11:23:33 EST 2003

I apologize; I have dealt with this so long, I forgot to mention that DHEA
is known to be low in schizophrenia.

"James Michael Howard" <jmhoward at arkansas.net> wrote in message
news:0hOdnY7vRLl4aN2iXTWJhg at arkansas.net...
> I have written Dr. Pantelis, et al., about this and another report, Aust N
> J Psychiatry. 2003 Aug;37(4):399-406.  I thought you may be interested in
> explanation of this:
> "I have developed an explanation of schizophrenia that may explain your,
> al., hypotheses. It is my hypothesis that low dehydroepiandrosterone
> prenatally and / or postnatally reduce brain growth and development. (My
> principal hypothesis is that DHEA evolved because DHEA optimizes
> and transcription of DNA. Therefore, all tissues, especially neural
> are affected by availability of DHEA.) Early lack of DHEA would produce
> brain structures of less robust growth which would be vulnerable to
> phenomena; this is the "early neurodevelopmental insult." Following growth
> and development, DHEA acts to maintain and activate the brain. It is known
> that DHEA exerts very positive effects on neural structures.
> I also suggest the hormones cortisol and testosterone (in men and women)
> adversely affect availability of DHEA. Therefore, a precipitating,
> events near/around puberty will combine to adversely affect the
> of DHEA and adversely affect brain function. (It is my hypothesis that
> cortisol, in fact, evolved to counteract the effects of DHEA; this is my
> explanation of the 'fight or flight' response.) Since it is known that
> cortisol is a neurotoxin, cortisol would adversely affect function and
> structure, especially in a person of low DHEA. The early lack of
> due to low DHEA would produce weak structures. Continued exposure to
> cortisol and testosterone would eventually cause degenerative changes in
> easily affected structures, with more robustly built structures succumbing
> later. Therefore, symptoms would appear sequentially, the type dependent
> upon brain development. So, the same mechanism could explain various kinds
> of differential destruction of brain structures and the timing of such.
> Brain "shrinkage" is a phenomenon of all aging, given a sufficient life
> span. I suggest this is due to the natural loss of DHEA of old age.
> Schizophrenia would exhibit early shrinkage as a result of earlier loss of
> DHEA and the combined actions of cortisol, the natural antagonist of DHEA.
> invite you to read my explanation of schizophrenia at
> www.anthropogeny.com/physiology.html ; simply scroll down to "other" to
> schizophrenia or do a search for 'schizophrenia.' "
> James Michael Howard
> Fayetteville, Arkansas, U.S.A.
> "lumberjack" <wfwoodland at yahoo.com.au> wrote in message
> news:1e7476e8.0308171859.5d126ea3 at posting.google.com...
> > The following might be of interest to the list ...
> >
> > Brain shrinkage: early sign of schizophrenia?
> >
> > The brains of people in the early stages of schizophrenia shrink twice
> > as fast normal, Australian researchers have found, suggesting a
> > possible new way to treat the illness.
> >
> > http://www.abc.net.au/science/news/stories/s925547.htm

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