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Rat study shows exposure to Ecstasy early in pregnancy induces brain changes

Jasbird Jasbird#dead-mail-box# at myrealbox.com
Fri Aug 29 23:42:24 EST 2003

Rat study shows exposure to Ecstasy early in pregnancy induces brain
Researchers have shown that 21-day-old rat pups exposed in the womb to
the drug MDMA (3,4-methylenedioxymethamphetamine, often called
Ecstasy) during a period corresponding to the first trimester in human
pregnancy exhibit changes in brain chemistry and behavior. "Existing
data suggest that most women who use MDMA stop taking it when they
learn they are pregnant," says NIDA Director Dr. Nora D. Volkow. "But
the animal studies that linked this drug to neurobiological changes
and learning impairments were conducted in situations analogous to the
third trimester in humans. This study sought to investigate a more
true-to-life situation by looking at the consequences of Ecstasy
exposure early in pregnancy." 
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More bullshit from NIDA.

: Dr. Jack W. Lipton, doctoral student James Koprich, and their 
: colleagues injected 8 pregnant rats twice daily with MDMA from day 14 
: through day 20 of pregnancy, 

But people don't do MDMA twice daily over a 7 day period. They usually
do it only once or twice per week or less.

: a period corresponding to the first 3 months of human fetal
: development. The scientists injected saline 
: twice daily during the same period to another 8 pregnant rats. The 
: researchers examined brain tissue of the rat pups when they were 21 
: days old. A 21-day-old rat pup is roughly equivalent to a 2- to 
: 6-year-old child.

These 'correspondences' between people and rats are pretty dubious.
Animal biology doesn't work like that. Human development is much
slower and is different, so how can anyone know what kind of dosing
regimen 'corresponds' between people and rats or that any kind of
regimen does.

: "Our most striking finding was that 21-day-old MDMA-exposed pups had a 
: 502-percent increase in the number of dopamine neuron fibers in the 
: frontal cortex compared with control animals," notes Dr. Lipton. 
: Abnormal or overly numerous connections in the frontal cortex may 
: result in aberrant signaling there, possibly resulting in abnormal 
: behavior.

Every NIDA study uses huge quantities of MDMA to show that MDMA is
toxic in huge quantities.  I recommend that people don't do huge
amounts of MDMA - especially not several times per night nor several
days at a time.

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