CR Neuroprotection (meal size & rate)

Ian Goddard igoddard at erols.mom
Tue Feb 11 21:28:52 EST 2003

J Neurochem 2003 Feb;84(3):417-31 

Meal size and frequency affect neuronal plasticity and vulnerability
to disease: cellular and molecular mechanisms.

Mattson MP, Duan W, Guo Z.

Laboratory of Neurosciences, National Institute on Aging, Gerontology
Research Center, Baltimore, Maryland, USA.

Although all cells in the body require energy to survive and function
properly, excessive calorie intake over long time periods can
compromise cell function and promote disorders such as cardiovascular
disease, type-2 diabetes and cancers. Accordingly, dietary restriction
(DR; either caloric restriction or intermittent fasting, with
maintained vitamin and mineral intake) can extend lifespan and can
increase disease resistance. Recent studies have shown that DR can
have profound effects on brain function and vulnerability to injury
and disease. DR can protect neurons against degeneration in animal
models of Alzheimer's, Parkinson's and Huntington's diseases and
stroke. Moreover, DR can stimulate the production of new neurons from
stem cells (neurogenesis) and can enhance synaptic plasticity, which
may increase the ability of the brain to resist aging and restore
function following injury. Interestingly, increasing the time interval
between meals can have beneficial effects on the brain and overall
health of mice that are independent of cummulative calorie intake. The
beneficial effects of DR, particularly those of intermittent fasting,
appear to be the result of a cellular stress response that stimulates
the production of proteins that enhance neuronal plasticity and
resistance to oxidative and metabolic insults; they include
neurotrophic factors such as brain-derived neurotrophic factor (BDNF),
protein chaperones such as heat-shock proteins, and mitochondrial
uncoupling proteins. Some beneficial effects of DR can be achieved by
administering hormones that suppress appetite (leptin and ciliary
neurotrophic factor) or by supplementing the diet with
2-deoxy-d-glucose, which may act as a calorie restriction mimetic. The
profound influences of the quantity and timing of food intake on
neuronal function and vulnerability to disease have revealed novel
molecular and cellular mechanisms whereby diet affects the nervous
system, and are leading to novel preventative and therapeutic
approaches for neurodegenerative disorders.

PMID: 12558961 [PubMed - in process] 



  "To lengthen thy life, lessen thy meals." Benjamin Franklin

  Caloric Restriction: http://users.erols.com/igoddard/cr.htm

  Ongoing CR-monkey-study update: "In the monkeys...those on
  reduced feeding since the study started are dying at a rate 
  that is about half that of the monkeys receiving a full food
  ration." Associated Press: Eating less may extend human life.
  August 1, 2002 : http://www.msnbc.com/news/788746.asp?0si=- 

More information about the Neur-sci mailing list

Send comments to us at biosci-help [At] net.bio.net