"r norman" <rsnorman_ at _comcast.net> wrote in message
news:9djn5vkh0ooo3l0a743kf9vsglnu0fnv84 at 4ax.com...
> It is fairly "common" for synapses to release more than one
> transmitter. That is, peptides and "small-molecule" transmitters
> are often released together (cotransmission). And multiple peptides
> all processed from a single precursor protein can also be released
> together.
>> According to Levitan and Kaczmarek (The Neuron, 3rd Ed, Oxford,
> 2002, p. 250):
> There is now convincing histochemical evidence that some
> neurons contain one or more neuropeptides and a classical
> neurotransmitter, packaged in different vesicles but often present
> in the same synaptic terminal. ... In several cases it has been
> been found that only the classical transmitter is released by
> low-frequency stimulation, and corelease of the peptide
> requires short bursts of high-frequency stimulation. ... The
> coexistence of different neurotransmitters in distinct vesicle
> populations within a single neuron allows that neuron to
> produce different effects on a postsynaptic target, depending
> on the precise pattern of stimulation.
To take this one step further, for what purpose would 2 neurotransmitters be
released? Would one of them act as an inhibitor?
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