Neuron / neurotransmitter selection question

Gary Frank garyfrankNOSPAM at itol.com
Wed Feb 26 19:39:58 EST 2003

"r norman" <rsnorman_ at _comcast.net> wrote in message
news:9djn5vkh0ooo3l0a743kf9vsglnu0fnv84 at 4ax.com...

> It is fairly "common" for synapses to release more than one
> transmitter.  That is, peptides and "small-molecule" transmitters
> are often released together (cotransmission).  And multiple peptides
> all processed from a single precursor protein can also be released
> together.
> According to Levitan and Kaczmarek (The Neuron, 3rd Ed, Oxford,
> 2002, p. 250):
>    There is now convincing histochemical evidence that some
>     neurons contain one or more neuropeptides and a classical
>     neurotransmitter, packaged in different vesicles but often present
>     in the same synaptic terminal. ... In several cases it has been
>     been found that only the classical transmitter is released by
>     low-frequency stimulation, and corelease of the peptide
>     requires short bursts of high-frequency stimulation.  ... The
>     coexistence of different neurotransmitters in distinct vesicle
>     populations within a single neuron allows that neuron to
>     produce different effects on a postsynaptic target, depending
>     on the precise pattern of stimulation.

To take this one step further, for what purpose would 2 neurotransmitters be
released?  Would one of them act as an inhibitor?

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