minature inhibitor postsynaptic currents

BilZ0r BilZ0r at TAKETHISOUThotmail.com
Thu Sep 16 18:59:35 EST 2004

r norman <rsn_ at _comcast.net> wrote in
news:oj8kk055kltot3a30r5395vdvq9bsrmguh at 4ax.com: 

>>Thank you very much, so minature potentiatals would always be of the
>>same size? So agonists at presynaptic receptors which inhibit calcium 
>>channels, would effect the rate of minature potentials, but not there 
>>amplitude, while the same agonist would effect the rate and amplitude
>>of spontaneous potentials?
> Minis are often of a consistent size, but not always.  Depending on
> just where you are recording, they can vary for several reasons:
> different quantities of transmitter release or different distances
> from the recording site. They do show variation, though, sometimes
> with substantial variance even though there is a single peak in the
> amplitude histogram. 
> Agents that influence vesicle release tend to alter the frequency but
> not the amplitude.  Agents that influence postsynaptic response tend
> to alter the amplitude but not the frequency.  
> I don't understand the last half of your last statement.  You seem to
> make a distinction between miniature potentials and spontaneous
> potentials when I just told you they were the same thing.

Oh... I thought spontaneous potentials were the result of sponateous 
firing of a neuron, as against evoked firing.

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