[Neuroscience] Paired-pulse facilitation or inhibiton.

SJM Guzman jose.guzman at medizin-uni-leipzig.de
Mon Dec 12 13:19:33 EST 2005

Dear newsmembers:

I am just reading about cellular electrophysiological access to study 
presynaptic or postsynaptic effect of different drugs and substances. 
Apart of miniature EPSCs analysis, I found in the literature that some 
people are applying two consecutive pulses (S1 and S2) at brief time 
intervals to analyze the ratio of the second stimulation over the first 

If this ratio is >1 they talk about paired-pulse facilitation (PPF), if 
S2/S1<1 they call it paired-pulse inhibition (PPI)....

My question is... are those effects always presynaptic? if yes, why?

Thank you very much in advance.

Segundo JM Guzman

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