It's my analysis that what has been
referred to as "the engram" exists
in the 3-D Geometry of the endo-
plasmic reticulum and the way that
that 3-D Geometry focuses the ion-
forces" that tune "the genome".
This hypothesis is Testable both ob-
servationally and experimentally.
1. Observational methods:
If this hypothesis is correct, the
endoplasmic reticulum will exhibit
progressive modification during
the course of experience, and this
will reflect increasing information-
So this predicted circumstance can
be either confirmed or disproven
via observation of the 3-D Geomet-
ries of neurons' endoplacmic reticula
that have experienced 'normal' activ-
ation over various periods of clock-
A variation on this observational
method would be to train subjects
with respect to specifically-narrow
If the hypothesis is correct, such
narrowly-defined experience will
be correlated to =realtively= narrow
activation, which will(?) result in
riticulum 3-D Geometry.
[I'm not saying it's "easy" :-]
The variations [experience-dependent
geometrical skewing] will be subtle.
2. Experimental methods:
These are literally limitless, but they
all entail achieving some ability to
alter the 3-D Geometry of living en-
doplasmic reticula, while monitoring
cellular activation dynamics.
This would be an ideal use of sliced
preparations because the goal is not
to understand the slice's contribution
to global function. Rather, all that's
being sought is knowledge with respect
to the way that alterations of the 3-D
Geometry of endoplasmic reticula
alter(?) activation 'states' that are
monitorable within the slice.
Here, a positive result confirms the
hypothesis, and a negative result dis-
These experiments are exceedingly-
delicate because, of course, mechan-
ical perturbations =must= effect neur-
But there has to be a way to do this.
Pharmacological methods that might
be useful in testing the hypothesis
would include anything that could
selectively act with respect to the 3-D
Geometry of the endoplasmic retic-
ulum while leaving everything else in
the cellular structure 'uneffected'. [Fun-
ny-quotes, here, because it's right in
the hypothesis that the 3-D Geometry
of the endoplasmic reticulum tunes
"the geonme" with respect to a neur-
on's ongoing activation-experience,
so modifying the 3-D Geometry of
the endoplasmic reticulum will(?) al-
ter the unfolding of virtually every-
thing else that occurs within the cell.]
There's a lot more that's involved.
I've been discussing the 3-D energy-
dynamics involved for the past 'dec-
ade' here in b.n, and recently dis-
cussed it again in cap.
The net dynamics involved are 'just'
molecular 'level' TD E/I-minimization.
If the hypothesis is correct, it'll open
the door to a whole new approach
to all facets of molecular dynamics,
and, of course, the thing to do =first=
will be to thoroughly analyze the depths
of all that's correlated to the hypothe-
sized 3-D-Geometry "correlations".
Anyway, this is one of the things I
was going to discuss, in more detail,
in my "1:14" posts. The other thing
is in Physics, and I'm not going to get
K. P. Collins