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On The Engram

kenneth collins kenneth.p.collins at worldnet.att.net
Sat Jan 15 04:20:18 EST 2005

"kenneth collins" <kenneth.p.collins at worldnet.att.net> wrote in message
news:RR_Fd.19316$w62.19055 at bgtnsc05-news.ops.worldnet.att.net...
| [...]

| These experiments are exceedingly-
| delicate because, of course, mechan-
| ical perturbations =must= effect neur-
| onal activation.
| [...]

It was not clear, in my prior post, why
I referred to "mechanical perturbations".

It was in the larger discussion that I'd
worked-up but didn't post.

=Anything= that alters the Geometry
of a neuron's endoplasmic reticulum
can be used to test the stated hypoth-
esis -- including mechanical pressure
that, by any means, distorts that Ge-
ometry from its otherwise naturally-
occurring 'state' [which is, itself, prob-
ably highly-dynamic].

I also didn't discuss how it is that this
Geometry constitutes(?) "the engram".

Again, it's not a "letters in a book"
kind of thing. Rather, it's a cellular
"memory" of how the cell's experience
has tuned the cell's "behavioral" rep-
etoir, and through which it, subse-
quently, tunes it's functionality with
respect to specific inputs.

Encoding "the engram" within a dyn-
amic 'spherical' Geometry, which is
what the endoplasmic reticulum is, is
extremely-robust be-cause the 'state'
information that can be crammed into
such is =Huge=. [I've not yet been
able to find any limit for it.] And, yet,
access to the stored 'state' information
is simple, easy and completely "ad-
dressable" via the Topologically-dis-
tributed "Coulomb forces" that are
right-there, anyway, as a result of
the ionic conductances that occur
within and around every neuron.

[There's much more.]

k. p. collins 

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