In article <1h9vo38.7xo2e21khgx9cN%usenet02 at out-of-phase.de>,
usenet02 at out-of-phase.de (Christian Wilms) wrote:
> Something for the inhibition experts out there:
>> I'm looking for a drug that will prevent or at least reduce the
> desensitization of GABA-A receptors. Basically a GABAeric version of
> cyclothiazide.
Surely you'd have to find a way to sterically hinder the action of
whatever is desensitising the receptors? What's desensitising them?
I can tell you that allopregnanolone is a potent endogenous potentiator
of the GABA-A receptor, but it would be a pain to deliver in a
controlled way - it's a steroid so you usually have to use very sticky
vehicle.
