[Neuroscience] Re: Neuronal activity in the brain

Fijoy George via neur-sci%40net.bio.net (by tofijoy from yahoo.co.in)
Sat Oct 28 11:33:21 EST 2006

Thanks, Dr. Norman. I am sure these references will help.


"r norman" <r_s_norman from _comcast.net> wrote in message 
news:67g2k2div0460pjeq49fh8rfgfs3f0g4f4 from 4ax.com...
> On Fri, 27 Oct 2006 08:50:04 +1000, Matthew Kirkcaldie
> <m.kirkcaldie from removethis.unsw.edu.au> wrote:
>>In article <ehqgcn$9r7$1 from mailhub227.itcs.purdue.edu>,
>> "Fijoy George" <tofijoy from yahoo.co.in> wrote:
>>> In fact, I am a student (in
>>> Computer Science) currently working on the EEG/MEG neural source imaging
>>> problem, and I wanted to know how to correctly simulate activation 
>>> patches
>>> on the cortical surface.
>>I sympathise with your problem!  Unfortunately I think there's little
>>available guidance to suggest a "correct" way, because we don't know
>>what kinds of neuronal activity produce fMRI signal.  Are you wanting to
>>map the electrical EEG domain to the fMRI domain?  That sounds like an
>>interesting problem and I will have a dig around to see what I can turn
>>up.  Maybe Dr Agmon or Dr Norman could suggest some resources. My first
>>thought is the Brain Dynamics group here in Sydney, Australia - they
>>have produced models of EEG power spectra based on simple anatomical
>>properties of bulk cortical tissue.  I don't think they have applied it
>>to correlation with fMRI though - although the members do use fMRI in
>>experimental contexts.
>>Hope that helps - it's much easier to know how to advise when you say
>>what you're trying to achieve!
> It's rather out of my own experience, but you could start with
> Nikos K. Logothetis, Jon Pauls, Mark Augath, Torsten Trinath and Axel
> Oeltermann
> Nature 412, 150-157 (12 July 2001)
> "Neurophysiological investigation of the basis of the fMRI signal"
> http://www.nature.com/nature/journal/v412/n6843/abs/412150a0.html
> Jueptner M, Weiller C
> "Review: does measurement of regional cerebral blood flow reflect
> synaptic activity? Implications for PET and fMRI."
> Neuroimage. 1995 Jun;2(2):148-56.
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9343597&dopt=Citation
> Arien J. Smith , Hal Blumenfeld , Kevin L. Behar , Douglas L. Rothman
> , Robert G. Shulman , and Fahmeed Hyder
> "Cerebral energetics and spiking frequency: The neurophysiological
> basis of fMRI "
> PNAS | August 6, 2002 | vol. 99 | no. 16 | 10765-10770
> http://intl.pnas.org/cgi/content/abstract/99/16/10765
> David Attwell and Costantino Iadecola
> "The neural basis of functional brain imaging signals"
> TRENDS in Neurosciences Vol.25 No.12 December 2002
> http://people.hnl.bcm.tmc.edu/jli/reference/5.pdf
> S. Sheth, M. Nemoto, M. Guiou, M. Walker, N. Pouratian, A. Toga
> "Linear and Nonlinear Relationships between Neuronal Activity, Oxygen
> Metabolism, and Hemodynamic Responses"
> Neuron, Volume 42, Issue 2, Pages 347-355
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15091348&dopt=Abstract
> Robert G. Shulman1, Douglas L. Rothman1,2, Kevin L. Behar3 and Fahmeed
> Hyder
> "Energetic basis of brain activity: implications for neuroimaging"
> TRENDS in Neurosciences Vol.27 No.8 August 2004
> http://fcm.uncu.edu.ar/3-Posgrado/bases_moleculares/shulman%202004.pdf
> P M Matthews and P Jezzard
> Functional magnetic resonance imaging
> Journal of Neurology Neurosurgery and Psychiatry 2004;75:6-12
> http://jnnp.bmjjournals.com/cgi/content/abstract/75/1/6
> There is a lot more, but these, plus the references in them, will keep
> you busy for a while.

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