[Neuroscience] Dynorphine A acerbates pain producing/promoting bradykinin receptors

Entertained by my own EIMC via neur-sci%40net.bio.net (by write_to_eimc from ozemail.com.au)
Sat Apr 7 08:20:57 EST 2007

Nature Neuroscience - 9, 1465 - 1467 (2006)

Opioid, cheating on its receptors, exacerbates pain

Christophe Altier & Gerald W Zamponi

The authors are at the Hotchkiss Brain Institute, Department of Physiology 
and Biophysics, University of Calgary, 3330 Hospital Drive NW, Calgary, 
Alberta T2N 4N1, Canada. zamponi from ucalgary.ca

Opioids are commonly thought of as compounds that alleviate pain. A new 
study finds that elevated levels of the opioid dynorphin can unexpectedly 
activate bradykinin receptors, contributing to the maintenance of 
neuropathic pain.

It would be good if this finding is what it evidently is, namely an 
abberation; One that still allows categorizing (especially the creation of 
voluminous categories) to be a crucially important crutch for people 
preferring to contemplate things comprehensively.


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