[Neuroscience] Re: Concept of apoptosis

britches At kittymail.com via neur-sci%40net.bio.net (by britches At kittymail.com)
Mon Jan 22 12:01:52 EST 2007

On question 4 maroon is supposed to be neuron! Sorry!

britches At kittymail.com wrote:
> Hello everyone,
> I am not sure if this is the best place to ask for answers on my
> questions, but I thought I should consult the experts. Recently in a
> class I asked a few questions and was informed that the teacher simply
> didn't know. These questions are framed from a very basic physiology of
> psychology text.
> These were my questions about the topic of apoptosis, I am refering to
> the text in them, you can ignore that! Here are the questions I had
> sent to my proffessor:
> The Carlson text talks about apoptosis. I understand that apoptosis is
> death of a cell due to a chemical signal it receives that activates
> sort of self destruct genetic code inside the cell. However I have two
> questions about this process. In reference to the founder cells that
> help develop the ventricular zone, the text talks about them receiving
> these "chemical signals" that turn on their self destruct genes, during
> the end of the cortical development.
> 1.Where specifically are these chemical signals coming from? Where are
> they created?
> 2. By what mechanism are they transmitted?
> 3.  How does the creators and transmitors (answers to one and 2) know
> to release them, by what process is this accomplished?
> Another area directly relating to the apoptosis topic I need some
> clarification on is that of neuron apoptosis. The text states that
> neurons die by process of apoptosis. However, it then goes on to state
> that neurons migrate and find a space or nitch for themselves, when it
> finds its nitch, the postsynaptic cell creates and gives it a signal
> that LETS it live or tells it to continue living. However, when a
> neuron migrates and finds that a space is already taken, it dies. So
> there is no chemical signal being sent to the neuron that dies, it dies
> from a lack of a signal?
> 4. If the maroon dies because it does not get a chemical signal, how is
> this the same as apoptosis?
> 5. Does this mean that neurons have an automatically set up to destruct
> and only by chemical permission they then do no self-destruct?
> 6. The text uses the word "permits" in reference to the life giving
> signal from the postsynaptic cell to the surviving neuron, does this
> then mean that the postsynaptic cell does in fact send a chemical to
> kill any neurons attempting to move into an already occupied space?
> 7. What happens to the expired neuron tissue? Is it cleaned? Absorbed?
> etc.
> So if anyone can shed some light on any of these questions that would
> be fantastic, or point me in a direction where I might find the
> answers. 
> Thanks for any and all help. 
> -Stacy

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