Hello Rick,
ad (1):
- no. Neither concerning type of channel (gating mechanism, ion
permeablility, "speed"), nor concerning tissue type (neurons vs. muscle
for example), nor concerning distribution in one cell (axons vs. soma,
Ranvier's vs. myelin sheath).
ad (2):
- kind of yes, but: rarely is one type of channel (isoform)
representative for only one type of cell
ad (3):
- probably not, as ionchannel-distribution is one way of "specializing"
in cells, which occurs as well in vertebrates as in invertebrates.
For a quite comprehensive overview on sodium channels see
Goldin, A. L. (1999) Diversity of mammalian voltage-gated sodium
channels. Ann N Y Acad Sci 868, 38-50.
Goldin, A. L. (2001) Resurgence of sodium channel research. Annu Rev
Physiol 63, 871-894.
Or have a look at my (German) thesis at
http://deposit.ddb.de/cgi-bin/dokserv?idn=982011482&dok_var=d1&dok_ext=pdf&filename=982011482.pdf
Good luck with your project!
Michael
Rick Giuly schrieb:
> Hello All,
>> I'm interested in modeling neurons and I have a few questions:
>> (1) In adult animals, are ion channel distributions constant?
>> (2) Do particular cell types have well defined ion channel
> distributions that are similar among all cells of the type? (For
> example does a Purkinje cell have a predictable ion channel
> distribution?)
>> (3) Are the answers to questions (1) and (2) different for vertebrates
> and invertebrates?
>> Any comments or paper recommendations are appreciated. I've done some
> literature searching and found some fragments of information on these
> topics but nothing definitive yet.
>> -Rick
