Please see the also this paper:
Riedemann T, Polder HR, Sutor B (2016) *Determination and compensation
of series resistances during whole-cell patch-clamp recordings using an
active bridge circuit and the phase-sensitive technique*.
Pflügers Archiv - European Journal of Physiology, October 2016, Volume
468, Issue 10, pp 1725–1740, http://dx.doi.org/10.1007/s00424-016-1868-8
A method which avoids any series resistance can be found in the
following paper (sharp electrode and whole cell patch recordings):
Richter DW, Pierrefiche O, Lalley PM, Polder HR (1996) *Voltage-clamp
analysis of neurons within deep layers of the brain.* J Neurosci
Methods. <https://www.ncbi.nlm.nih.gov/pubmed/?term=richter+polder#>
1996 Aug;67(2):121-3.
PDF available under this link
<https://www.researchgate.net/publication/14333724_Voltage-clamp_analysis_of_neurons_within_deep_layers_of_the_brain>
Best regards
Hans Reiner Polder
support from npielectronic.com
Am 21.10.2016 um 22:17 schrieb mathewjones from wisc.edu:
> On Friday, November 23, 2012 at 4:36:59 PM UTC-6, Jeffrey Lopez wrote:
>> Hi everybody, there is a question I have since some time but still
>> dont have a convinvcing answer.
>> When your series resistance changes during a patch clamp experiment,
>> 1- which influence does it have on my EPSP slope and amplitude?
>> 2-why?
>> 3-how would it help or not to use a discontinuous (switching) amplifier?
>> If anyone could help me to understand I will appreciate it, please
>> try to be explicit in answering. Thanks a lot in advance!
> This page has a very nice explanation of why series resistance, pipette capacitance, and also the non-negligible effect of amplifier input impedance introduce artifacts and filtering of signals in current clamp:
>>http://www.billconnelly.net>>
