New Nerve Transmitter Overturns Long-Cherished Laws
kpaulc at earthlink.netABCXYZ
Thu Nov 11 11:16:09 EST 1999
thank you for the stuff you've posted... i replied with a longer post,
earlier this day, but it's nowhere to be found... except in the archives i
HURRAH+++***!!! for you, James.
ken (K. P. Collins)
James Teo wrote:
> Using the term transmitter is awfully strong, since it seems to act
> only to modulate an existing transmitter's receptor.
> However, it has long been known that glia releases some substances
> which are known to act as neurotransmitters. Adenosine, BDNF,
> aspartate, and my personal speciality: glutamate, the most common
> neurotransmitter in the whole brain. (Read my abstract in Teo et al
> Proceedings of the British Pharmacological Society, July 1999,
> page P83). Hopefully I might get a publication from that.
> Anyways, as far as I am aware all of the studies have only been done
> in vitro, since it is impossible to distinguish between astrocyte
> release and neuronal release in in vivo models. Even some primary
> cultures are problematic, since they may be contaminated with
> neurones. My study is done on a immortal cell line (C6 glioma) so
> there is little fear of contamination.
> Other references outlining the 'glial heresy' against the dogma of the
> Bezzi et al 1998, Nature 391, pages 281-285
> Jeftinija et al 1996, Journal of Neurochemistry 66(2), pages 676-684
> Parpura et al 1994, Nature 369, page 744-747
> Steinhauser & Gallo 1996, Trends in Neurosciences 19(8), pages 339-345
> Stella et al 1994, Journal of Neuroscience 14(2), pagesd 568-575
> Smith, S (1996) Current Biology (can't remember exactly)
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