From BIOSCI-REQUEST  Tue Jun  6 08:02:13 1995
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Date: Tue, 6 Jun 95 08:15:20 EDT
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Subject: Research Positions

                              RESEARCH SCIENTISTS


                       NEW APPROACHES TO CROP PROTECTION


The DuPont Company is seeking highly motivated research scientists to join a
multidisciplinary team working to exploit modern biological methods in the
discovery and development of novel products for the control of weeds and plant
diseases.  Applicants should be proven problem solvers, capable of working and
communicating effectively in a diverse group of biochemists, chemists,
molecular geneticists and biologists.  Strong computer skills are a must.
Successful candidates will join teams in Wilmington and Newark, Delaware.  Our
Mid-Atlantic location offers a wide range of academic, cultural and
recreational activities.

DUPONT AGRICULTURAL PRODUCTS

Molecular Biologist

The Biochemical Discovery Section is searching for a molecular biologist with a
strong background in biochemistry and analytical methods.  The individual will
work with a team that has the objective of discovering new herbicides and
fungicides through the design of novel screening technology and the elucidation
of biochemical modes of action.  Minimum requirements for the position include
a Ph.D. in the biological sciences (e.g., molecular biology, biochemistry,
fungal or plant physiology) with experience in intermediary metabolism and
analytical techniques.  Training in the biology of filamentous fungi and
plant-fungus interactions is desirable.  Applicants should respond to DuPont
Human Resources PO Box 30-MB, Newark, DE 19714.



Analytical Biochemist

The Biochemical Discovery Section is seeking an analytical biochemist to join a
team working to identify new molecular targets for crop protection chemistry.
The successful applicant will aid in the discovery of biologically active
compounds that interact specifically with these targets.  Responsibilities for
this position include characterizing metabolic flux in selected pathways, as
well as determining rates of uptake, translocation and metabolism of
xenobiotics in plants and fungi.  Minimum requirements for the position include
a Ph.D. in the biological or chemical sciences (e.g., biochemistry, fungal or
plant physiology) with experience in intermediary metabolism and analytical
techniques.  Familiarity with HPLC, GC, NMR and/or mass spectrometry is
strongly recommended.  Some knowledge of organic chemistry, enzyme mechanisms
and molecular biology is highly desirable.  Applicants should respond to DuPont
Human Resources, PO Box 30-AB, Newark DE 19714.


DUPONT CENTRAL RESEARCH & DEVELOPMENT

Yeast Molecular Geneticist

The Biological Sciences Section is searching for a scientist with a Ph.D. in
yeast molecular genetics.  Applicants should have postdoctoral experience, with
demonstrated ability to develop an active research program in yeast molecular
and cellular biology.  The objective will be to apply the power of modern yeast
biology to the identification and characterization of molecular targets for
novel crop protection products.  The successful candidate will join an
interdisciplinary team that includes scientists in DuPont Agricultural
Products.  Information generated will be applied to the discovery and
development of herbicides and fungicides by screening combinatorial chemistry
libraries and by designing target-directed inhibitors.  Experience in
biochemistry is desirable, along with the ability to establish effective
interactions with biologists, chemists and specialists in bioinformatics.
Applicants should respond to DuPont Human Resources, PSS-0106, Wilmington, DE
19898.


Interested candidates should forward their resumes and a list of references by
July 3, 1995.


DuPont is an equal opportunity employer.
                                                                                

From BIOSCI-REQUEST  Wed Jun 14 20:13:50 1995
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From: James Brown <james.brown@bbsrc.ac.uk>
Message-ID:  <7310251813061995/A11865/JIIS/11966C990800*@MHS>
To: Rust-mildew <rust-mil@net.bio.net> (Non Receipt Notification Requested)
Subject:  cost of resistance
Sensitivity:  Private

Here's a rusty-mildewy question:

There's quite a literature on costs of race-specific virulence - testing whether
or not unnecessary virulence reduces fitness, and if so, by how much. My
question is, does anyone know anything about fitness costs of race-specific
resistance genes? I emphasise _race-specific_ resistance, because the question I
have in mind relates to the recognition-response model of gene-for-gene
interactions: if a resistance gene product differs from the product of an allele
of that gene because of a difference in the conformation of a part of the
molecule which acts as a receptor of an avirulence gene product, would that
necessarily cause any difference in the fitness effects of the alleles?

The only paper I know of is by J.H. Joergensen & H.P. Jensen (1990) Norsk
Landbruksforksning, supplement 125-130 "Effect of 'unnecessary' powdery mildew
resistance genes on agronomic properties on spring barley". They didn't identify
any cost.

I'll post a summary of interesting, non-confidential replies.

James Brown
_______________________________________________________

Dr J. K. M. Brown,
Cereals Research Department, John Innes Centre,
Colney Lane, Norwich, NR4 7UH, England
Phone: (+44)(0) 1603 452571. Fax: (+44)(0) 1603 502241.
E-mail: james.brown@bbsrc.ac.uk

From BIOSCI-REQUEST  Thu Jun 15 09:33:48 1995
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Date: Thu, 15 Jun 1995 15:12:55 +0000
To: rust-mil@net.bio.net
From: Peter G Isaac <peter_isaac@nickbio.demon.co.uk>
Subject: yr17 breakdown
Message-ID:  <9506151505.aa19808@post.demon.co.uk>

I received a copy of the following press release, and thought people might
be interested.

Pete Isaac
Nickerson BIOCEM

-----------------
NEW YELLOW RUST RACE IDENTIFIED AT THE NIAB

A new race of Yellow Rust has been identified on wheat in inoculated
poly-tunnel tests at the NIAB in Cambridge. This new race has virulence for
the Rendezvous yellow rust resistance (Yr17) and some Rendezvous
derivatives. So far  this particular race of yellow rust has only been
observed in enclosed, irrigated conditions and as yet there is no evidence
of field infection. The existence of this race indicates that the
Rendezvous yellow rust resistance may no longer be effective and the
following varieties on the 1995 NIAB Recommended List are at risk from this
breakdown - Brigadier, Hussar and Beaufort. Crops of these varieties should
be monitored to ensure that infection is not a problem in the field.


A more comprehensive testing programme will be put in to place during the
1995/6 season to assess a wider range of varieties, which may be at risk.
This will be carried out under field conditions in order to evaluate
degrees of infection, in order to update NIAB resistance ratings.


Should this particular race become widespread, wheat growers in high Yellow
Rust risk areas would be best advised to limit their acreage of susceptible
varieties. Some varieties in the same diversification group as Rendezvous
related varieties (DG1) will not be affected by this race change as their
resistance is based on other genetic factors. A routine prophylactic
spraying policy may be necessary for some 'at risk' varieties, as is
currently practiced with other varieties such as Riband.
-----------------------------



From BIOSCI-REQUEST  Thu Jun 29 11:33:36 1995
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From: Les@puccini.crl.umn.edu
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Newsgroups: bionet.mycology
Date: Thu, 29 Jun 95 13:18:56 PDT
Subject: Book: The Rust Fungi of Cereals, Grasses and Bamboos
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Greetings all.

I have been trying to locate a copy of G.B Cummins book: "The Rust Fungi of 
Cereals, Grasses and Bamboos", 1971.  This book is out of print and 
Springer-Verlag does not have any more copies.  If someone has a copy they 
would like to sell or know of a place that I can get a copy, I would appreciate 
 it.

Thanks

Les Szabo


