Alternate conformation in NMR structure ?

[Alexandre Bonvin]

Emmanuel Brun wrote:
> 
>         Does someone know if X-plor allow to refine alternate
> conformation for structure determined by NMR ??
> 
> Thanks
> 
Do you mean by that multi conformer refinement (ensemble averaging)?
If yes this has been done. Have a look at my home page for some
examples as well as some sample scripts, and here are two references:

A.M.J.J. Bonvin and A.T. Brunger
" Conformational variability of solution nuclear magnetic resonance
structures."
J. Mol. Biol. 250, 80-93 (1995). 

  A.M.J.J. Bonvin and A.T. Brunger
"Do NOE distances contain enough information to assess the relative
populations of multi-conformer structures?"
J. Biomol. NMR. 7, 72-76 (1996).

Cheers,
Alexandre

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