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Postdoctoral Position at Cold Spring Harbor

Leemor Joshua-Tor leemor at CSHL.ORG
Wed Aug 7 08:24:40 EST 1996


A postdoctoral position is available at Cold Spring Harbor Laboratory in
either of two areas:

        1. Structural and biochemical studies of a unique DNA-binding
protease. Gal6 (yeast bleomycin hydrolase) is a conserved protease that
limits the use of the anti-cancer drug bleomycin. We are combining
structural and biochemical information of the protein, its complexes and
various mutants, along with yeast molecular biology and genetics which is
done in collaboration with Stephen Johnston at Southwestern Medical Center
at Dallas, to study its functions and conserved cellular role. See:
        L. Joshua-Tor, H. E. Xu, S. A. Johnston and D. C. Rees, Crystal
Structure of a Conserved Protease That Binds DNA: The Bleomycin Hydrolase,
Gal6, Science, 269, 945-950 (1995).

        2. Structural studies of complexes of eukaryotic transcription
factors. We are combining structural studies with genetic information to
study the molecular interactions important for transcriptional activation
in eukaryotes.

Our X-ray crystallography facilities include an R-axis detector equipped
with an Oxford cryosystem, several graphics workstations and have access to
the nearby National Synchrotron Light Source (NSLS) at Brookhaven. We also
have state-of-the-art facilities for carrying out biochemical and molecular
biology studies. Cold Spring Harbor provides a unique stimulating
environment for rich scientific interactions.

The positions are available for highly motivated applicants with a Ph. D.
and experience in either: (a) protein crystallography or a related field;
or (b) those with experience in biochemistry or molecular biology and a
keen interest in protein crystallography and structural biology. Please
send CV, list of publications, a summary of research experience and
interests, and names and numbers of three references to Dr. Leemor
Joshua-Tor, Cold Spring Harbor Laboratory, P. O. Box 100, Cold Spring
Harbor, NY 11724. Tel. (516) 367 8821. For additional information please
call or send e-mail to leemor at cshl.org

  Leemor Joshua-Tor, Ph.D.
  Cold Spring Harbor Laboratory           Tel. (516) 367 8821
  1 Bungtown Road                         Fax  (516) 367 8873
  Cold Spring Harbor, NY 11724            e-mail: leemor at cshl.org

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