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[Protein-crystallography] Postdoc position in acoustic crystal preparation and high throughput screening at NSLS II

Soares, Alexei via xtal-log%40net.bio.net (by soares from bnl.gov)
Tue Oct 28 09:44:30 EST 2014


Postdoctoral Research Associate =96 Macromolecular Crystal Preparation for =
NSLS-II

2-year Term Position


BNL Overview:

Brookhaven National Laboratory is a nonprofit research and development inst=
itution whose purpose is to advance ideas and knowledge through a multidisc=
iplinary program of basic and applied research.


Project Overview:

A postdoctoral position is available to develop new crystal-preparation tec=
hnologies to advance the use of serial macromolecular crystallography (MX) =
at NSLS-II. This new synchrotron will soon begin operation at Brookhaven Na=
tional Laboratory. The individual will develop technologies for crystalliza=
tion, drug discovery, and crystal handling to make serial crystallography p=
ossible, using various technologies, including acoustic droplet ejection (A=
DE).


The project will provide the capability for experimenters to employ nanolit=
er quantities of material to produce specimens for diffraction studies with=
 a large number of discrete experiments in a small area. This will exploit =
the micro-beam capabilities of NSLS-II MX beamlines; both room temperature =
and cryogenic serial crystallography strategies will be explored. High-thro=
ughput screening will be used for different types of structural biology pro=
jects (crystallization conditions, fragment binding, etc). The individual w=
ill work closely with a broad technology-development team. Our team members=
 have different areas of expertise, from 3D labware design to research on m=
edically relevant expressed proteins. No experience with ADE is necessary.


Essential Duties and Responsibilities:

The successful candidate will assist in the development and implementation =
of procedures and computer algorithms that leverage the Echo 550 instrument=
 for macromolecular crystallography applications for serial crystallography=
 applications in the few-nanoliter regime. The candidate will also develop =
novel technologies as well as improve existing technologies, and will have =
opportunities to participate in other related projects in a large and diver=
se group.


Required Knowledge, Skills and Abilities:

  *   Ph.D. in an appropriate chemistry, biology, or physics discipline; st=
ructural biology, crystallography, or a related field will have preference

  *   Demonstrated experience (preferably including publications) in innova=
tive experimentation and/or methods development with crystallography or dru=
g discovery

  *   Experience with conventional crystallization, and familiarity with mi=
cro crystallization and handling of micro crystals will be valuable

  *   Experience in computer programming

  *   The candidate must have a demonstrated ability to work with a team.


Other Information:

BNL policy states that Research Associate appointments may be made to those=
 who have received their doctoral degrees within the past five years.


Please apply to Job # 137 on our jobs website:


http://www.bnl.gov/HR/careers/


At Brookhaven National Laboratory we believe that a comprehensive employee =
benefits program is an important and meaningful part of the compensation em=
ployees receive.  Our benefits program includes but is not limited to:

  *   Medical Plans

  *   Vacation

  *   Holidays

  *   Dental Plans

  *   Life Insurance

  *   401(k) Plan

  *   On-site Child Development Center, Swimming Pool, Weight room Tennis C=
ourts, and many other employee perks and benefits.


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