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Funds For Life Extension Research: Fed or Private

Don Ashley dashley at TENET.EDU
Thu Feb 16 09:15:27 EST 1995

What is a 'Lifescan' believer?  An infomorph?  

Can you elaborate more on 'Downloading' concept.

You may be on to something, here.  If it will promote funds for research, 
let's expand on it.


On Thu, 16 Feb 1995, Eugen Leitl wrote:

> On Wed, 15 Feb 1995, Patrick O'Neil wrote:
> 1> 
> 1> 
> 1> On Wed, 15 Feb 1995, Eugen Leitl wrote:
> 1> 
> 1> > 1> Increasing expression of superoxide-dismutase and other 
> 1anti-oxidation
> 1> > 1> enzymes; this will make the body more resistant to free radicals,
> 1> > 1> environmental dangers and perhaps slow aging somewhat.
> 1> > 
> 1> > Probably true. Difficult to estimate additional life span in years.
> 1> 
> 1> There is a present balance in its production verses a biological need for 
> 1> free radicals.  If you simply increase expression of free radical 
> 1> quenchers such as SOD, you are insured to dork up biologically important 
> 1> radical reactions in regards to nucleic acid synthesis, electron 
> 1> transport, immune response, and a host of others known and unknown.  The 
> 1> body's balance of expression vs inhibition of various enzymes is set for 
> 1> best performance under the circumstances.  I am not saying that any 
> 1> increase in expression is sure to screw up the works, but on the other 
> 1> hand, it is not just as simple as saying, "Ah, free radical scavenger.  
> 1> Just increase the expression of that gene and viola!  Happy, healthy 
> 1> body!"  There are many other things involved that would have to be 
> 1> considered.  None of the enzymatic systems within our bodies are 
> 1> completely independent of other reactions.
> Essentially, I'm on your side. I've written in this and the last
> posting that messing with human biochemistry is highly unlikely
> to bring us true immortality. I am a LifeScan and Download believer.
> Yet if there is some primitive (or elaborate) device which would
> allow me to hop around for 30-40 years more (instead of lying as 
> a lump of brain tissue in a liquid nitrogen tank (provided I will 
> ever have the necessary pocket money)) I might at least witness the
> emergence of the necessary technology, if not work on it.
> 1>   
> 1> > 1> Increase of DNA correction rate by increasing expression of 
> 1repair enzymes
> 1> > 1> These two methods don't appear that hard to use, since we only 
> 1need to
> 1> > 1> create more copies or promoters for the genes (evolution haven't 
> 1done > > 1this,
> 1> > 1> since it would require more energy (which we humans have plenty 
> 1of) and > > 1> long lifespan is normally not selected for).
> 1> > 
> 1> > Very true and sound arguments.
> 1> 
> 1> But...All the repair enzymes in the world will not stop mutation.  You 
> 1> may decrease mutation rate somewhat but there are mutations that can get 
> 1> past all the editing machinery.  Reducing mutation rate, in any case, 
> 1> would only help to reduce the occurrence of cancer, not affect lifespan 
> 1> outside of cancer.
> I have already said that other sources of death, as accidents, 
> ilnesses as cancer, etc. make a prolonged life not eternal. 
> If an infomorph's hardware home box is blasted, he's revived 
> in another location, loosing only the time since last backup. 
> (Distributed redundant storage _has_ a lot of merits ;)
> 1>   On another note, natural selection favors a certain minimal level of 
> 1> mutation in order that diversity is evolved, thus allowing for adaption 
> 1> to exist in the first place.
> I am an Evolutionist and use GAs on my computer. Yet if I am
> an individual suffering from fatal intreatable cancer, arisen
> from essentially the same mutation/crossover process which is
> the driving force of evolution I don't care a fig for adaptation.
> It is entirely clear that a population of immortal individuals 
> does not evolve. 
> Unless it wishes to. Do you care for Darwinian or Lamarckian 
> evolution? Or a pleasant mix of both of them? You're free 
> to choose. That is the nice point in the Downloading concept:
> freedom to do anything you did before (including the death
> _option_), plus More. How much more, is only limited by the
> amount of computation at you disposal and your imagination.
> It's Man-made Heaven, all right.
> 1> 
> 1> Patrick
> 1> 
> Eugene.

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