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Coles and Harris' CoQ10 Study (was Re: A4M Discussion)

Robert Luly luly at netcom.com
Tue Feb 28 12:48:29 EST 1995


Robert Luly (luly at netcom.com) wrote:
: Hello Brian
: I was at that talk in Vegas and I got a copy of the slides from Dr. Coles.
:  I heard Dr. Regelson say something similar when quoting a friend regarding
: DHEA replacement vs: natural reduction of hormone levels. That is maybe this 
: reduction *extends* life and should not be restored to youthful levels.
:  Regarding the Coles slides I noticed that the 80% to 20% survival slope was 
: about the same for controls and the test animals. The max survival was also
: the same. However *ALL* the CoQ-10 group was shifted to the right by 
: about 30 %. That looks like a positive effect to me. 
: Regards
: R. Luly 
 I just re-read your post. Do you mean that the right shift in AVG 
lifespan should have shifted the MAX lifespan as well but was *possibly*
prevented by all the increased activity of the CoQ-10 mice?
BTW I understand that mice use CoQ-9 in their natural biochemestry not 
CoQ-10 but I don't know if that makes any difference.
Luly 
: Brian Manning Delaney (bmdelane at ellis.uchicago.edu) wrote:
: : In article <Pine.SOL.3.91.950227233436.28647A-100000 at corona>,
: : Patrick O'Neil  <patrick at corona> wrote:
: : >
: : >
: : >On Tue, 28 Feb 1995, Brian Manning Delaney wrote:
: : >> I thought this study was quite interesting. CoQ had no effect on max.
: : >> life span, but had a fairly significant effect on avg. life span
: : >> (experimental animals had about a 20% greater avg. life span).
: : >> Autopsies showed that cause of death was essentially the same for both
: : >> groups. The effect of CoQ was just to delay the onset of lymphoma. The
: : > 
: : >The CoQ you refer to...is it coenzyme Q?  If so, then perhaps the fact 
: : >that it is utilized in electron transport and ATP generation might help 
: : >explain greater physical activity (more efficient/proficient electron 
: : >transport?).  If you do not refer to coenzyme Q, then...nevermind.
: : >
: : >Would you clarify for me?

: : Yes, sorry, coenzyme Q10 is the drug/"nutrient" in question. I think
: : it's quite likely indeed that its role in ATP generation explains the
: : diff. levels of activity seen between the two groups. But my main
: : point was that "youthification" may not always mean a longer life
: : span, in part because the symptoms of aging could be protective in
: : some way. Ex: some (but not all) studies have shown declining levels
: : of CoQ w/age in rats. Maybe the slower metabolism this produces
: : actually slows aging (lower consequent rate of free-rad. production,
: : etc.).

: : -- 
: : Brian M. Delaney <b-delaney at uchicago.edu> [DO NOT cc: articles to me.]
: : <bmdelane at midway.uchicago.edu> [Wrists: "Leave unambiguous typos."]
: : Note: All statements in this article are in jest; they are not
: : statements of fact. * "Mein Genie ist in meinen Nuestern." -Nietzsche.




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