I was at that talk in Vegas and I got a copy of the slides from Dr. Coles.
I heard Dr. Regelson say something similar when quoting a friend regarding
DHEA replacement vs: natural reduction of hormone levels. That is maybe this
reduction *extends* life and should not be restored to youthful levels.
Regarding the Coles slides I noticed that the 80% to 20% survival slope was
about the same for controls and the test animals. The max survival was also
the same. However *ALL* the CoQ-10 group was shifted to the right by
about 30 %. That looks like a positive effect to me.
Brian Manning Delaney (bmdelane at ellis.uchicago.edu) wrote:
: In article <Pine.SOL.3.91.950227233436.28647A-100000 at corona>,
: Patrick O'Neil <patrick at corona> wrote:
: >On Tue, 28 Feb 1995, Brian Manning Delaney wrote:
: >> I thought this study was quite interesting. CoQ had no effect on max.
: >> life span, but had a fairly significant effect on avg. life span
: >> (experimental animals had about a 20% greater avg. life span).
: >> Autopsies showed that cause of death was essentially the same for both
: >> groups. The effect of CoQ was just to delay the onset of lymphoma. The
: >The CoQ you refer to...is it coenzyme Q? If so, then perhaps the fact
: >that it is utilized in electron transport and ATP generation might help
: >explain greater physical activity (more efficient/proficient electron
: >transport?). If you do not refer to coenzyme Q, then...nevermind.
: >Would you clarify for me?
: Yes, sorry, coenzyme Q10 is the drug/"nutrient" in question. I think
: it's quite likely indeed that its role in ATP generation explains the
: diff. levels of activity seen between the two groups. But my main
: point was that "youthification" may not always mean a longer life
: span, in part because the symptoms of aging could be protective in
: some way. Ex: some (but not all) studies have shown declining levels
: of CoQ w/age in rats. Maybe the slower metabolism this produces
: actually slows aging (lower consequent rate of free-rad. production,
: Brian M. Delaney <b-delaney at uchicago.edu> [DO NOT cc: articles to me.]
: <bmdelane at midway.uchicago.edu> [Wrists: "Leave unambiguous typos."]
: Note: All statements in this article are in jest; they are not
: statements of fact. * "Mein Genie ist in meinen Nuestern." -Nietzsche.